Comparing intravenous clonidine and nalbuphine for attenuating hemodynamic response to laryngoscopy and improving perioperative outcomes in laparoscopic surgeries

The Department of Anaesthesia at SPMC Bikaner approved the trial and it was carried out during laparoscopic surgery OT with proper informed written permission. study a double-blind, randomised, prospective interventional trial. comprised 60 (ASA) Classes I II patients between ages 18 who were scheduled for elective cholecystectomy. Using computer-generated random number sequence, divided into two groups 30 each: Group A received 1.5 mg/kg clonidine, whereas B received.2 nalbuphine in 50 ml NS solution. Prior to administering drug, five minutes after premedication, hemodynamic parameters recorded. Double-blind administration medication occurred more than 10 before anaesthesia onset. Hemodynamic recorded following medication, 1 5 intubation, prior pneumoperitoneum, minutes, 20 40 finally extubation. minute intubation (and pneumoperitoneum post extubation), discovered that there substantial difference heart rate, SBP, DBP, MAP B. In our investigation, hemodynamics related rate improved clonidine. Based on results other earlier research conducted by different authors, we came conclusion both clonidine nalbuphine, when administered undergoing surgery, attenuated response surgery. systolic diastolic blood pressure, mean arterial pressure is much less which leads us produced greater nalbuphine.